Current Issue : January-March Volume : 2015 Issue Number : 1 Articles : 5 Articles
A colloidal drug delivery system (CDDS) based on a novel surface modification process help to reserve the constraining activity of surfaces is described. Aquasome a nanoparticle submicronic structure (diameter below 1 µm) made up with carbohydrates. They received much attention to develop a drug delivery system as an alternative to liposome technology in order to overcome the problems related to the stability of these vesicles in biological fluids. Aquasome a molecular carrier, consist of ceramic core (colloidal precipitation) to which glassy carbohydrates are then allowed to adsorb as a nanometer thick surface coating, is formed, which is then absorbed with pharmaceuticals. The carbohydrate coating functions as a dehydroprotectant and stabilizes subsequently non-covalently bound immobilized members of biochemically reactive surface members such as pharmaceuticals. Many of the physical properties of this enabling system have been characterized in vitro and in animal models. It has got a quite versatile application potential as a carrier for delivery of vaccines, haemoglobin, drugs, dyes, enzymes and even genetic material....
Emulgel is the most emerging and successful formulation to deliver hydrophobic drugs. It imbibes the properties of both gel and emulsion which results in enhancing the solubility of the hydrophobic drug to make the drug more bioavailable and enhances the patient compliance as topical drug delivery dosage form. Aceclofenac is NSAID, derivative of diclofenac, used as analgesic and anti-inflammatory agent belongs to BCS class – II drug (low solubility and high permeability) is taken as a drug of choice to formulate as Emulgel. It facilitates in by-passing the drug from GI exposure, hence it reduces the gastric complications of the drug. Less dose is sufficient to prepare as topical dosage form. Here, emulgels were prepared as 1.5% w/w formulation by using carbopol 934 and HPMC K4M separately as gelling agents. Mentha oil as penetration enhancer. Emulgels were prepared and evaluated for rheological properties, pH determination, drug release profiles and skin irritation tests. The present study reveals that the formulation using carbopol 934 shown better release profile than HPMC K4M which depicts, carbopol 934 is the better choice of polymer to prepare aceclofenac emulgel....
Administering therapeutic moiety via the pulmonary route signifies a leading contest in pulmonary medicine. This route has been used for numerous treatments, but with room for progression. Novel respiratory medicines need an additional steadfast and effective dosing regimen to narrow therapeutic directories with a strong need of enhanced deposition in the lungs. Dry powder formulations are of great interest in pulmonary delivery. They provide advantages to traditional suspension and nebulized droplet formulations with ease of administration and simple device design. Using nano carriers, designed with an effective surface modification can be employed for the delivery using dry powder inhalation devices for an effective delivery of the drug moiety within the deep respiratory system, which could be further used for improving drug bioavailability and efficacy, via enhanced recital into the system specifically formulated in a dry powder inhalable device....
Microspheres are small spherical particles, with diameters in the micrometer range typically 1 μm to 1000 μm. Microspheres are sometimes referred as micro particles. Microspheres form homogeneous, monolithic particles which improve the treatment by providing localization of the drug at the site of action and by prolonging the drug release. The objective of the present study was to formulate sustained release microspheres of tramadol hydrochloride using egg albumin as release retarding agent. From FTIR studies it was conformed that no interactions were found between TH and polymers. The maximum yield of the microspheres was found to be 96.99% and the encapsulation efficiency was found to be 65.2%. The prepared albumin microspheres released the drug completely within 7 hours at lower drug to polymer ratio. At ratio of more than 1:2, the drug release was sustained over a period of 10 hours. The microspheres were discrete, spherical and uniform in shape. The particle size was of the microspheres was found to be 99.6 μm. The prepared microspheres showed minor changes in particle size only under stability study with no appreciable change in drug content proving good stability of the product conducted in accelerated condition. The present study signifies the utility of microspheres in retarding the drug release. This may in turn reduces the frequency of dosing, thereby improving the patient compliance....
This study describes the formulation and evaluation of mucoadhesive buccal gels for curcumin delivery via buccal mucosa. In the present study the polymer with well-defined mucoadhesive properties like carbopol 934 was used. Carbopol- poloxamer gels of 1% curcumin was formulated with various absorption enhancers like polyethylene glycol, mannitol and sodium lauryl sulphate by cold method. Since curcumin is having bioavailability problem it has been formulated in gel form using absorption enhancers like polyethylene glycol, mannitol and sodium lauryl sulphate. The gels were characterized for gelation temperature, pH, viscosity, drug release profile, kinetic analysis of drug release data, drug content and stability studies. Sodium lauryl sulphate was found to be better absorption enhancer as compared to other absorption enhancers as it was showing better % drug release....
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